the comparison of plasma d-dimer levels in benign and malignant tumors of cervix, ovary and uterus.

background: thromboembolism is the most important complication of cancers.the aim of this study was to determine d-dimer levels in benign and malignant tumors of the uterus, ovary and cervix. subjects and methods: this was a cross sectional study and it was conducted on 90 female patients referred to imam khomeini and arash hospitals because of uterine, cervical and ovarian tumors in 2013-2014. after surgical resection or tissue biopsy, 2 cc of each patient’s blood was taken to be sent to laboratory of hospitals. “nycocard” kit was chosen to measure d-dimer levels in mg/lit by neflumetry method. data were analyzed in spss-16 by t-test and one-way anova test. results: the highest mean of d-dimer was 3.9 (± 2.9sd) in malignant cervical tumors. the mean plasma levels of d-dimer in malignant uterine cancers (p = 0.008), ovarian cancers (p = 0.007) and cervical cancers (p = 0.006) was significantly higher than benign tumors. in all three types of uterine, ovarian and cervical cancers, d-dimer was significantly higher in advanced stages than lower stages. conclusion: the plasma d-dimer levels in patients with malignant tumors of the uterus, cervix and ovary were higher than benign types. by increasing the stage of gynecologic malignant tumors, the levels of plasma d-dimer were increased.